An affliction is something that causes pain and mental suffering, especially a medical condition.

When you ameliorate a bad condition or situation, you make it better in some way.

If you deal with a difficult situation with aplomb, you deal with it in a confident and skillful way.

When you are under another person’s auspices, you are being guided and protected by them.

A bastion is considered an important and effective defense of a way of life or principle; a bastion can also refer to a heavily fortified place, such as a castle.

When something bedevils you, it causes you a lot of problems and difficulties over a period of time.

If you are beset by something, you are experiencing serious problems or dangers because of it.

If you circumvent something, such as a rule or restriction, you try to get around it in a clever and perhaps dishonest way.

Complacent persons are too confident and relaxed because they think that they can deal with a situation easily; however, in many circumstances, that is not the case.

When you compromise someone’s safety, you put it in danger in some way.

A contagion is a disease—or the transmission of that disease—that is easily spread from one person to another through touch or the air.

If something daunts you, it makes you worried about dealing with it because you think it will be very difficult or dangerous.

Something that is deleterious has a harmful effect.

Something detrimental causes damage, harm, or loss to someone or something.

A dilemma is a difficult choice between two equal alternatives.

If something discomfits you, it makes you feel embarrassed, confused, uncomfortable, or frustrated.

If something disconcerts you, it makes you feel anxious, worried, or confused.

When someone feels disquiet about a situation, they feel very worried or nervous.

If a fact or idea eludes you, you cannot remember or understand it; if you elude someone, you manage to escape or hide from them.

If you exhibit equanimity, you demonstrate a calm mental state—without showing upset or annoyance—when you deal with a difficult situation.

When someone is exonerated from guilt, a task, or a responsibility, they are set free or excused from it.

If something is formidable, it is impressive in size, power, or skill; therefore, it can make you feel frightened, alarmed, or in awe because it is so powerful or difficult to deal with.

A fortification is a structure or building that is used in defense against an invading army.

An imbroglio is a very difficult, confusing, and complicated situation.

An impasse is a difficult situation in which progress is not possible, usually because none of the people involved are willing to agree.

If someone is impassive, they are not showing any emotion.

An impenetrable barrier cannot be gotten through by any means; this word can refer to parts of a building such as walls and doors—or to a problem of some kind that cannot be solved.

If someone is imperturbable, they are always calm and not easily upset or disturbed by any situation, even dangerous ones.

If you are impervious to things, such as someone’s actions or words, you are not affected by them or do not notice them.

An impregnable fortress or castle is very difficult to defeat or overcome; an opinion or argument of that same quality is almost impossible to successfully change or challenge.

Someone who has an indomitable drive refuses to give up under any circumstances.

When a spy infiltrates enemy lines, they creep in or penetrate them so as to gather information.

Something innocuous is not likely to offend or harm anyone.

Something that is insidious is dangerous because it seems harmless or not important; nevertheless, over time it gradually develops the capacity to cause harm and damage.

An internecine conflict or quarrel takes place between people who belong to the same group, organization, country, etc.

If you are inured to something unpleasant, you have become so used to it that it no longer affects you.

Someone or something that is invulnerable cannot be harmed in any way; hence, they or it is completely safe or secure.

A leviathan is something that is very large, powerful, difficult to control, and rather frightening.

Something or someone that is maleficent deliberately tries to cause harm or evil.

A malevolent person or thing is evil due to deliberate attempts to cause harm.

Malice is a type of hatred that causes a strong desire to harm others both physically and emotionally.

A miasma is a harmful influence or evil feeling that seems to surround a person or place.

If you mitigate something that causes harm, you reduce the harmful or painful effects of it.

If you mollify someone, you say or do something to make that person feel less angry or upset.

Someone who is nonchalant is very relaxed and appears not to be worried about anything.

Something that is noxious is harmful, extremely unpleasant, and often poisonous.

To obviate a problem is to eliminate it or do something that makes solving the problem unnecessary.

A pathogen is an organism or infectious agent—such as a bacterium or virus—that causes disease.

A perilous situation is highly dangerous or extremely risky.

Something that is pernicious is very harmful or evil, often in a way that is hidden or not quickly noticed.

If you are in a plight, you are in trouble of some kind or in a state of unfortunate circumstances.

A precarious situation or state can very quickly become dangerous without warning.

If you are in a predicament, you are in a difficult situation or unpleasant mess that is hard to get out of.

Something that is propitious shows favorable conditions.

A quagmire is a difficult and complicated situation that is not easy to avoid or get out of; this word can also refer to a swamp that is hard to travel through.

If you are in a quandary, you are in a difficult situation in which you have to make a decision but don’t know what to do.

A salubrious place or area is pleasant, clean, healthy, and comfortable to live in.

A salutary experience is beneficial to you since it strengthens you in some way, although it may be unpleasant as you undergo it; this word also refers to promoting good health.

Something sinister makes you feel that an evil, bad, or harmful thing is about to happen.

A stoic person does not show their emotions and does not complain when bad things happen to them.

Severe problems, suffering, or difficulties experienced in a particular situation are all examples of tribulations.

To be unfazed is to not be affected by something that happens to you, even if it is quite embarrassing or bothersome.

If a problem or situation is vexing, it puzzles, worries, or annoys someone.

Virulent feelings or actions are full of hatred and bitterness.